Estrogen receptor (ER)-β is thought to exert anti-proliferative effects in the normal prostate
but supports prostate cancer (PCa) cell survival. We previously reported that the receptor's …

Promoter methylation plays an important role in the inactivation of tumor suppressor genes
during tumorigenesis. We examined the methylation status of glutathione s-transferase Pi1 …

Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …

Background Folate and methyl‐group deficiency has been linked to prostate cancer
susceptibility, yet the mechanisms underlying these observations are incompletely …

Prostate cancer is the second most commonly diagnosed cancer in men in Poland after lung
cancer and the third leading cause of cancer-related mortality after lung and colon cancer …

Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …

Epigenetics describes the study of stable, reversible alterations to the genome that affect
gene expression and genome function, the most studied mechanisms are DNA methylation …

This study examined whether differential DNA methylation is associated with clinical
features of more aggressive disease at diagnosis and prostate cancer recurrence in African …

Three different kinds of alterations in DNA methylation have been observed in urological
malignancies. DNA hypermethylation of CpG-rich promoter regions is an important …

Androgen-independent metastatic prostate cancer is characterized by a heterogeneous loss
of androgen receptor (AR) expression among tumor cells. In this study, we evaluate DNA …