PURPOSE: Prostate cancer continues to be a prevalent disease in the United States and
western countries. Advances in the fields of molecular biology and genetics coupled with …

Bladder cancer is the fourth most common cancer in men in the United States, and its
recurrence rate is highest among all malignancies. The unmet need for improved strategies …

DNA methylation is known to be abnormal in all forms of cancer, but it is not really
understood how this occurs and what is its role in tumorigenesis. In this review, we take a …

The field of epigenetics has recently moved to the forefront of studies relating to diverse
processes such as transcriptional regulation, chromatin structure, genome integrity, and …

A critical need in understanding the biology of prostate cancer is characterizing the
molecular differences between indolent and aggressive cases. Because DNA methylation …

D-type cyclins play a pivotal role in cell cycle regulation and their abnormal expression was
associated with several human malignancies. To assess Cyclin D2 promoter methylation …

During cancer development and progression, tumor cells undergo abnormal epigenetic
modifications, including DNA methylation, histone deacetylation and nucleosome …

Human malignant tumors are characterized by pervasive changes in the patterns of DNA
methylation. These changes include a globally hypomethylated tumor cell genome and the …

Purpose: Loss or abnormal expression of Cyclin D2, a crucial cell cycle-regulatory gene, has
been described in human cancers; however, data for prostate tumors are lacking. We …

OBJECTIVES: Biochemical (prostate-specific antigen) recurrence of prostate cancer after
radical prostatectomy remains a major problem. Better biomarkers are needed to identify …