Cancer contributes to a large proportion of the mortality and morbidity in the United States
and worldwide. Despite advances in diagnosis and treatment of various cancers, early …

Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …

Cellular DNA undergoes profound changes in methylation during cancer development, with
hypermethylation occurring in specific gene promoters, amidst a backdrop of generalized …

Aberrant DNA methylation is ubiquitous in human cancer and has been shown to occur
early during carcinogenesis, thus providing attractive potential biomarkers for the early …

Abstract Changes in DNA methylation in cancer have been heralded as promising targets
for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite …

While different markers for cancer diagnosis have been known for at least a decade, the
systematic search for biomarkers emerged only several years ago. In this article, I will …

In light of the high incidence and mortality rates of cancer, early and accurate diagnosis is an
important priority for assigning optimal treatment for each individual with suspected illness …

Aberrant DNA methylation is associated with cancer development and progression. There
are several types of specimens from which DNA methylation pattern can be measured and …

Life expectancy rises steeply when a tumor is diagnosed at an early stage. Therefore,
diagnosing cancer before it turns into an aggressive, barely curable disease is one of the …