DNA methylation plays a crucial role in the regulation of gene expression and chromatin
organization within normal eukaryotic cells. In cancer, however, global patterns of DNA …

DNA methylation plays an essential role in regulating cell growth and proliferation, and
disease. Changes in aberrant DNA methylation are disease-specific, and, accordingly, the …

The number of epigenetic studies is exponentially increasing. There is anticipation that DNA
methylation may close gaps in our understanding of disease etiology, and how certain risk …

Circulating tumor nucleic acids in blood have been demonstrated to reflect the biologic
characteristics of tumors. During tumor progression, aberrant DNA methylation can lead to …

A recent expansion of our knowledge about epigenetic changes strongly suggests that
epigenetic rather than genetic features better reflect disease development, and …

Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …

DNA methylation plays a critical role in the regulation of gene expression. The ability to
access the methylation status for a large number of genes or the entire genome should …

Background There has been a steady increase in the number of studies aiming to identify
DNA methylation differences associated with complex phenotypes. Many of the challenges …

DNA methylation, consisting of the addition of a methyl group at the fifth‐position of cytosine
in a CpG dinucleotide, is one of the most well‐studied epigenetic mechanisms in mammals …

Background: Alterations in DNA methylation play a key role in tumor initiation, and
methylation markers are well established for detecting various cancer types. Cancer-specific …