With the rapid development of genome-wide high-throughput technologies, including
expression arrays, SNP arrays and next-generation sequencing platforms, enormous …

DNA methylation profiles are in dynamic equilibrium via the initiation of methylation,
maintenance of methylation and demethylation, which control gene expression and …

DNA methylation is a biochemical process where a DNA base, usually cytosine, is
enzymatically methylated at the 5-carbon position. An epigenetic modification associated …

Aberrant DNA methylation is a major epigenetic mechanism of gene silencing in a wide
range of human cancers. Previous studies on DNA methylation typically used paired tumor …

DNA methylation is an epigenetic phenomenon influencing the normal function of DNA and
its scaffolding proteins. Especially in cancer, aberrant methylation patterns may contribute to …

DNA methylation is one among the major grounds of cancer progression which is
characterized by the addition of a methyl group to the promoter region of the gene thereby …

Epigenetic alterations by promoter DNA hypermethylation and gene silencing in cancer
have been reported over the past few decades. DNA hypermethylation has great potential to …

Background: DNA methylation is a highly characterized epigenetic modification of the
human genome that is implicated in cancer. The altered DNA methylation patterns found in …

Background Lung cancer is the leading cause of cancer death in men and women in the
United States and Western Europe. Over 160,000 Americans die of this disease every year …

DNA methylation is a key mechanism of epigenetic regulation that is frequently altered in
diseases such as cancer. To confirm the biological or clinical relevance of such changes …