Simple Summary As known breast cancer risk factors do not accurately predict the risk of
developing breast cancer, breast cancer screening is still based solely on age. At the …

Abstract Purpose of Review This manuscript orients the reader to the underlying motivations
of environmental biomarker development for human population studies and provides the …

Although the potential of biomarkers to aid in the early detection, diagnosis, prevention, and
treatment of breast cancer is broadly recognized and numerous biomarker candidates have …

DNA methylation plays a critical role in genome function both in health and disease. Almost
60 years after the discovery of 5-methyl cytosine and∼ 25 years since the discovery that …

DNA methylation, the modification of a cytosine nucleotide immediately preceding a guanine
base in a stretch of DNA, is rapidly gaining strength in the diagnostic field as a powerful tool …

Background DNA methylation biomarkers for early detection, risk stratification and treatment
response in cancer have been of great interest over the past decades. Nevertheless, clinical …

Recent advances in sequencing technologies provide unprecedented opportunities for
epigenetic biomarker development. Particularly the DNA methylation pattern—which is …

DNA methylation is the most studied epigenetic event in cancer, with focus being placed on
studying the entire DNA methylation landscape in specific cancers. Due to the recent …

Methylation of cytosines in cytosine–guanine (CpG) dinucleotides is one of the most
important epigenetic alterations in animals. The presence of methylcytosine in the promoter …

DNA methylation is a common mechanism of inactivation of tumour-suppressor and other
cancer genes in neoplastic cells. The advantages of gene methylation as a target for the …