The field of epigenetics has recently moved to the forefront of studies relating to diverse
processes such as transcriptional regulation, chromatin structure, genome integrity, and …

DNA methylation, or the covalent addition of a methyl group to cytosine within the context of
the CpG dinucleotide, has profound effects on the mammalian genome. These effects …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …

DNA methylation acts in concert with other epigenetic mechanisms to regulate normal gene
expression and facilitate chromatin organization within cells. Aberrant DNA methylation …

Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …

DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …

Epigenetic mechanisms are essential for normal development and maintenance of tissue-
specific gene expression patterns in mammals. Disruption of epigenetic processes can lead …

The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale multinational …

There is overwhelming evidence that DNA methylation patterns are altered in cancer.
Methylation of CG-rich islands in regulatory regions of genes marks them for transcriptional …

There is compelling evidence to support the importance of DNA methylation alterations in
cancer development. Both losses and gains of DNA methylation are observed, thought to …