Epigenetic alterations such as DNA methylation have been implicated in the development
and progression of various cancers. DNA methylation consists of the reversible addition of a …

Aberrant DNA methylation is known as an important cause of human cancers, along with
mutations. Although aberrant methylation was initially speculated to be similar to mutations …

The discovery of numerous hypermethylated promoters of tumour–suppressor genes, along
with a better understanding of gene–silencing mechanisms, has moved DNA methylation …

Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …

DNA methylation, mediated by the combined action of three DNA methyltransferases
(DNMT1, DNMT3A, and DNMT3B), is essential for mammalian development and is a major …

DNA methylation alterations are now widely recognized as a contributing factor in human
tumorigenesis. A significant number of tumor suppressor genes are transcriptionally …

Over three decades ago DNA methylation had been suggested to play a role in the
regulation of gene expression. This chapter reviews the development of this field of research …

The regulation of gene transcription is not simply dependent on the presence or absence of
DNA-binding transcription factors that turn genes on or off, but also involves processes …

DNA methylation is a significant regulator of gene expression, and its role in carcinogenesis
recently has been a subject of remarkable interest. The aim of this review is to analyze the …

DNA methylation is now recognized as an important mechanism regulating different
functions of the genome; gene expression, replication, and cancer. Different factors control …