The establishment of a cell identification method more accurate than the conventional
morphological and cell-type-specific marker analyses has been desired. DNA methylation is …

Epigenetic mechanisms such as histone modifications and DNA methylation extend the
information of the underlying genomic DNA sequence. Understanding cell type-specific …

Epigenetics refers to heritable phenotypic alterations in the absence of DNA sequence
changes, and DNA methylation is one of the extensively studied epigenetic alterations. DNA …

DNA methylation has been viewed as a stable component of the epigenome, which is
established during development and fixed thereafter. We show here using nearest neighbor …

Because each cell type has a unique epigenome to help provide cell specificity, the use of a
mixed cell population in the analysis of DNA methylation is a reflection of all cell types …

Early studies proposed that DNA methylation could have a role in regulating gene
expression during development [Riggs, AD (1975) Cytogenet. Cell Genet. 14, 9–25] …

The aim of this project was to develop a simple screening tool to measure the DNA
methylation of fibroblast cells, and to determine if differences in DNA methylation could be …

Background DNA methylation has been recognized as a key mechanism in cell
differentiation. Various studies have compared tissues to characterize epigenetically …

During mammalian development, it is essential that the proper epigenetic state is
established across the entire genome in each differentiated cell. To date, little is known …

DNA methylation is an epigenetic mechanism that is related to mammalian cellular
differentiation, gene expression regulation, and disease. In several studies, DNA …