Comment www. thelancet. com Vol 369 May 5, 2007 1497 infusions would clearly have
been beneficial. The regimen was explained to volunteers as:“For practical reasons, the time …

The axiom “before testing a new treatment in man, test it first in animals if possible” has been
part of drug development for the past 50 years or so. Testing in animal models is believed to …

We thank the correspondents for their responses to our Comment. 1 Although randomised
controlled trials (RCTs) that are rigorously designed, conducted, and analysed provide …

Although randomised controlled trials (RCTs) that are rigorously designed, conducted, and
analysed provide reliable and comprehensive information on the risks and benefits of …

The requirements for data collection during clinical trials of new drugs are rigorous.
Unexpected outcomes are as important as expected ones, and all adverse events should be …

The revolution in molecular medicine and cell biology that occurred in the late 20th century
was a magnet for research funding and continues to advance understanding of disease. By …

The Medicines Control Agency (MCA) consultation letter MLX287 (www. mca. gov. uk),
concerning the implementation of European Union directive 2001/20/EC on good clinical …

World Report clinical trials, insists that the estimate was if anything a conservative one.”
There's little doubt this has been a very salutary lesson. It is amazing how few people took …

The problem is clear: for every new drug that is approved, US $1 billion in research is spent,
10 years of development are required, and nine of every ten drugs fail. 1 With health-care …

The selection of comparators is another crucial point in assessing the value of new drugs.
Too often, placebo is still selected as the comparator, raising doubts about the clinical …