The ferric uptake regulator Fur has been reported to repress the expression of rmpA, a
regulatory gene for the mucoid phenotype, leading to decreased capsular polysaccharide …

A comparative proteomic analysis was utilized to evaluate similarities and differences in
membrane samples derived from the cariogenic bacterium Streptococcus mutans, including …

To replicate in mammalian hosts, bacterial pathogens must acquire iron. The majority of iron
is coordinated to the protoporphyrin ring of heme, which is further bound to hemoglobin …

While a polysaccharide capsule is known to be important for preventing phagocytosis of the
human pathogen Cryptococcus neoformans, other antiphagocytic pathways have been …

Iron is a nutrient of critical importance for the strict anaerobe Clostridium acetobutylicum, as
it is involved in numerous basic cellular functions and metabolic pathways. A gene encoding …

Background CpxAR is a two-component system that allows bacteria to reorganize envelope
structures in response to extracellular stimuli. CpxAR negatively affects type 1 fimbriae …

Stomach acid provides a significant innate barrier to the entry of the food-borne pathogen
Listeria monocytogenes into the human gastrointestinal tract. A key determinant of acid …

Abstract Knowledge of the genetic architecture of pathogen infectivity and host resistance is
essential for a mechanistic understanding of coevolutionary processes, yet the genetic basis …

Ferric uptake regulator (Fur) and Fur-like proteins form an important family of transcriptional
regulators in many bacterial species. In this work we have characterized a Fur-like protein …

Bacteria use two-component signal transduction systems (TCSs) to sense and respond to
environmental changes via a conserved phosphorelay between a sensor histidine kinase …