Amino acid biosynthetic pathways that are absent in mammals are considered an attractive
target for antifungal therapy. Leucine biosynthesis is one such target pathway, consisting of …

Iron homeostasis is strictly regulated by complex cascades connected with secondary
metabolism in bacteria. Ferric uptake regulators ('Fur's), siderophores, efflux systems, and …

Vertebrate hosts actively sequester iron, and fungal and other pathogens must therefore
adapt to a severe limitation in iron availability to cause disease. Recent studies reveal that …

The overall role of the Rcs phosphorelay in Proteus mirabilis is largely unknown. Previous
work had demonstrated that the Rcs phosphorelay represses the flhDC operon and …

The major capsular polysaccharide glucuronoxylomannan (GXM) of the pathogenic fungus
Cryptococcus neoformans has been associated with depression of a variety of …

In Klebsiella pneumoniae, we have previously shown that IscR, an Fe–S cluster-containing
transcriptional factor, plays a dual role in controlling capsular polysaccharide biosynthesis …

In the present study, we characterized the in vitro modulation of NETs (neutrophil
extracellular traps) induced in human neutrophils by the opportunistic fungus Cryptococcus …

Erysipelothrix rhusiopathiae, the causative agent of swine erysipelas, is a facultative
intracellular Gram-positive bacterium. It has been shown that animals immunized with a …

Cryptococcal disease is estimated to affect nearly a quarter of a million people annually.
Environmental isolates of Cryptococcus deneoformans, which make up 15 to 30% of clinical …

Haemophilus ducreyi causes the sexually transmitted disease chancroid and a chronic limb
ulceration syndrome in children. In humans, H. ducreyi is found in an abscess and …