A tight interplay of genetic predisposition and environmental factors define the onset and the
rate of progression of chronic renal disease. We are seeing a rapid expansion of information …

Genome-wide association studies (GWAS) have identified hundreds of loci associated with
kidney-related traits such as glomerular filtration rate, albuminuria, hypertension, electrolyte …

In order to change the current state of chronic kidney disease knowledge and therapeutics, a
fundamental improvement in the understanding of genetic and environmental causes of …

Over the past decade, genome-wide association studies (GWAS) have considerably
improved our understanding of the genetic basis of kidney function and disease. Population …

A current challenge in interpretation of genome-wide association studies is to establish the
mechanistic links between the measured genotype and observed phenotype. The …

Genome-wide association studies (GWASs) have advanced our understanding of the
genetic basis for common renal diseases, including chronic kidney disease (CKD) and …

Approaches to these CKD hotspots are of necessity becoming more holistic. Genetic studies
may help us identify the environmental triggers by teaching us about disease biology and …

Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as
well as genes for complex kidney diseases that manifest in combination with environmental …

The increasing numbers of patients with chronic kidney disease combined with no satisfying
interventions for preventing or curing the disease emphasize the need to better understand …

We saw impressive progress in our understanding of the genetics of kidney function and
disease in 2021. Genome-wide association studies defined key common variants for kidney …