This review provides an overview of the unique features of DNA methylation in the human
placenta. We discuss the importance of understanding placental development, structure …

As the 'gateway'to the fetus, the placenta is subject to a myriad of environmental factors,
each with the potential to alter placental epigenetic and gene expression profile. This can …

Epigenetic modifications, and particularly DNA methylation, have been studied in many
tissues, both healthy and diseased, and across numerous developmental stages. The …

Epigenetic variation is increasingly hypothesized as a mechanism underlying the effect of
the in utero environment on long-term postnatal health; however, there is currently little clear …

Epigenetic processes, such as DNA methylation, are known to regulate tissue specific gene
expression. We explored this concept in the placenta to define whether DNA methylation is …

The placenta acts not only as a conduit of nutrient and waste exchange between mother and
developing fetus, but also functions as a regulator of the intrauterine environment. Recent …

Throughout in utero development, the placenta plays a key role in controlling growth and
development. The placenta acts not only as a gatekeeper of nutrient and waste exchange …

The placenta, which plays a critical structural and functional role during pregnancy, is a key
link in the chain of events that lead to intrauterine programming of adult health. Placental …

Obtaining representative samples from a term placenta for gene-expression studies are
confounded by both within placental heterogeneity and sampling effects such as sample …

DNA methylation of CpGs located in two types of repetitive elements—LINE1 (L1) and Alu—
is used to assess “global” changes in DNA methylation in studies of human disease and …