The generation of memory is a cardinal feature of the adaptive immune response, involving
different factors in a complex process of cellular differentiation. This process is essential for …

Immune cells are one of the most complex and diverse systems in the human organism.
Such diversity implies an intricate network of different cell types and interactions that are …

To date, nearly 100 autoimmune diseases have been an area of focus, and these diseases
bring health challenges to approximately 5% of the population worldwide. As a type of …

Abstract Background Circulating CD4+ T helper cells are activated through interactions with
antigen presenting cells and undergo differentiation into specific T helper cell subsets …

Memory CD4+ T cells are central regulators of both humoral and cellular immune
responses. T cell differentiation results in specific changes in chromatin structure and DNA …

DNA demethylation has been found to occur at the promoters of a number of actively
expressed cytokines and is believed to play a critical role in transcriptional regulation. While …

Background There is considerable evidence that epigenetic mechanisms and DNA
methylation are critical drivers of immune cell lineage differentiation and activation …

Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding
RNAs are known regulators of gene expression and genomic stability in cell growth …

Upon recognition of an antigen, the differentiation of antigen-inexperienced naïve T
lymphocytes into subsets able to effectively coordinate host defense is controlled by a …

DNA methylation is a focus of epigenetic research in the immune system. This overview
begins with a synopsis of the players and processes involved in DNA methylation …