Scientists have been fascinated by the human brain for centuries, yet knowledge of the
cellular and molecular events that build the human brain during embryogenesis and of how …

Brain organoids recapitulate in vitro the specific stages of in vivo human brain development,
thus offering an innovative tool by which to model human neurodevelopmental disease. We …

The ability to reproduce early stages of human neurodevelopment in the laboratory is one of
the most exciting fields in modern neuroscience. The inaccessibility of the healthy human …

Three-dimensional (3D) brain organoids derived from human pluripotent stem cells hold
great potential to investigate complex human genetic states and to model aspects of human …

Our ability to study the developing human brain has recently been dramatically advanced by
the development of human'brain organoids', three-dimensional culture systems that …

Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …

Recent developments in 3D cultures exploiting the self‐organization ability of pluripotent
stem cells have enabled the generation of powerful in vitro systems termed brain organoids …

Brain organoids are self-assembled three-dimensional aggregates generated from
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …

The cerebral cortex forms early in development according to a series of heritable
neurodevelopmental instructions. Despite deep evolutionary conservation of the cerebral …

Understanding of human brain development, dysfunction and neurological diseases has
remained limited and challenging due to inability to recapitulate human brain-specific …