The von Hippel-Lindau tumor suppressor gene (VHL) is best known as an E3 ubiquitin
ligase that negatively regulates the hypoxia inducible factor (HIF). VHL mutations are the …

Inheritance of a faulty von Hippel-Lindau (VHL) tumor suppressor gene is the cause of VHL
disease, a rare multisystemic autosomal dominant disorder characterized by the …

Abstract The von Hippel–Lindau (VHL) tumor suppressor gene encodes an adaptor protein
that regulates an array of transcription-dependent and-independent cellular and …

Clear cell carcinoma of the kidney is a major cause of mortality in patients with von Hippel-
Lindau (VHL) disease, which is caused by germ line mutations that inactivate the VHL tumor …

Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene cause tissue-specific
tumors, with a striking genotype-phenotype correlation. Loss of VHL expression predisposes …

Germ line VHL tumor suppressor gene loss-of-function mutations cause von Hippel-Lindau
disease, which is associated with an increased risk of central nervous system …

pVHL (von Hippel-Lindau tumor suppressor protein) is the substrate recognition subunit of
the CBC VHL ubiquitin ligase complex promoting the degradation of hypoxia-inducible …

Mutations in VHL underlie von Hippel–Lindau (VHL) disease, a hereditary cancer syndrome
with several subtypes depending on the risk of developing certain combination of classic …

Abstract Loss of von Hippel–Lindau (VHL) protein function results in an autosomal-dominant
cancer syndrome known as VHL disease, which manifests as angiomas of the retina …

The physiologic response to changes in cellular oxygen tension is ultimately governed by a
heterodimeric transcription factor called hypoxia-inducible factor (HIF), which, in adaptation …