Temporal Modulation of DNA Methylation and Gene Expression in Monolayer and 3D Spheroids of Dental Pulp Stem Cells during Osteogenic Differentiation: A …

S Raik, R Thakur, V Rattan, N Kumar, A Pal… - Tissue Engineering and …, 2022 - Springer
Background: Human mesenchymal stem cells are being used for various regenerative
applications in past decades. This study chronicled a temporal profile of the transcriptional …

DNA methylation profile is associated with the osteogenic potential of three distinct human odontogenic stem cells

T Ai, J Zhang, X Wang, X Zheng, X Qin… - Signal transduction and …, 2018 - nature.com
Among the various sources of human autologous stem cells, stem cells isolated from dental
tissues exhibit excellent properties in tissue engineering and regenerative medicine …

Epigenetic regulation of dental pulp stem cell fate

D Zhou, L Gan, Y Peng, Y Zhou, X Zhou… - Stem Cells …, 2020 - Wiley Online Library
Epigenetic regulation, mainly involving DNA methylation, histone modification, and
noncoding RNAs, affects gene expression without modifying the primary DNA sequence and …

Roles of DNA methylation in influencing the functions of dental‐derived mesenchymal stem cells

L Shi, X Ye, J Zhou, Y Fang, J Yang, M Meng… - Oral …, 2023 - Wiley Online Library
Objective DNA methylation as intensively studied epigenetic regulatory mechanism exerts
pleiotropic effects on dental‐derived mesenchymal stem cells (DMSCs). DMSCs have self …

[HTML][HTML] Human dental pulp stem cells produce mineralized matrix in 2D and 3D cultures

M Riccio, E Resca, T Maraldi, A Pisciotta… - European journal of …, 2010 - ncbi.nlm.nih.gov
The aim of this study was to characterize the in vitro osteogenic differentiation of dental pulp
stem cells (DPSCs) in 2D cultures and 3D biomaterials. DPSCs, separated from dental pulp …

Epigenetic regulation of methylation in determining the fate of dental mesenchymal stem cells

H Zhang, H Fu, H Fang, Q Deng, H Huang… - Stem Cells …, 2022 - Wiley Online Library
Dental mesenchymal stem cells (DMSCs) are crucial in tooth development and periodontal
health, and their multipotential differentiation and self‐renewal ability play a critical role in …

Enriched trimethylation of lysine 4 of histone H3 of WDR63 enhanced osteogenic differentiation potentials of stem cells from apical papilla

S Diao, DM Yang, R Dong, LP Wang, JS Wang… - Journal of …, 2015 - Elsevier
Introduction Dental tissue–derived mesenchymal stem cells (MSCs) are a reliable cell
source for dental tissue regeneration. However, the molecular mechanisms underlying their …

Multilineage differentiation potential of human dental pulp stem cells—impact of 3D and hypoxic environment on osteogenesis in vitro

A Labedz-Maslowska, N Bryniarska, A Kubiak… - International journal of …, 2020 - mdpi.com
Human dental pulp harbours unique stem cell population exhibiting mesenchymal
stem/stromal cell (MSC) characteristics. This study aimed to analyse the differentiation …

Effect of histone demethylase KDM5A on the odontogenic differentiation of human dental pulp cells

QM Li, JL Li, ZH Feng, HC Lin, Q Xu - Bioengineered, 2020 - Taylor & Francis
Human dental pulp cells (hDPCs) possess the capacity to differentiate into odontoblast-like
cells in response to exogenous stimuli. Histone methylation is one of the most robust …

Osteoblasts can induce dental pulp stem cells to undergo osteogenic differentiation

Y Wang, J Yao, M Yuan, Z Zhang, W Hu - Cytotechnology, 2013 - Springer
Recent studies have shown that, in numerous species, systemically administered bone
marrow-derived mesenchymal stem cells undergo site-specific differentiation. This suggests …