The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. To date,
there is not a specific and approved treatment for NAFLD yet, and therefore, it is important to …

Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in Western countries and has
become a serious public health concern. Although Western-style dietary patterns …

Obesity and alcohol consumption synergistically promote steatohepatitis, and neutrophil
infiltration is believed to be associated with steatosis. However, the underlying mechanisms …

Non-alcoholic steatohepatitis (NASH) is associated with obesity and increased expression
of hepatic peroxisome proliferator-activated receptor γ (PPARγ). However, the relevance of …

Pathogenesis of steatohepatitis, a common liver disease, remains controversial. It is
proposed that fatty liver with a second hit capable of inducing necroinflammation results in …

Nonalcoholic steatohepatitis with fibrosis is a more severe form of nonalcoholic fatty liver
disease, one of the most common liver diseases. We have previously shown that …

Peroxisome proliferator activated receptor α (PPARα) acts as a fatty acid sensor to
orchestrate the transcription of genes coding for rate-limiting enzymes required for lipid …

Peroxisome proliferator-activated receptor-γ (PPARγ) is a transcription factor that regulates
lipid metabolism and inflammatory responses. Certain PPARγ ligands improve nonalcoholic …

The present study was performed to examine a hypothesis that peroxisome proliferator-
activated receptor γ (PPARγ) is implicated in high fat diet-induced liver steatosis. Mice were …

Objective. The pathogenesis of non-alcoholic steatohepatitis is still unclear. We have
demonstrated previously that peroxisome proliferator activated receptor gamma (PPARγ) …