Epigenetic regulation allows heritably modulating gene expression profiles without
modifying the primary sequence of gDNA. Under physiologic conditions, epigenetic patterns …

Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

Epigenetic mechanisms, including DNA methylation, histone post-translational
modifications, and chromatin structure regulation, are critical for the interactions between …

Dysregulation of the epigenome drives aberrant transcriptional programmes that promote
cancer onset and progression. Although defective gene regulation often affects oncogenic …

Background Epigenetic mechanisms regulate chromatin accessibility patterns that govern
interaction of transcription machinery with genes and their cis-regulatory elements …

Recently, immunotherapeutic approaches have shown impressive responses in a subset of
cancer patients. However, the rate of success is low and a large percentage of treated …

Cancer development involves both genetic and epigenetic alterations. Aberrant epigenetic
modifications are reversible, allowing excellent opportunities for therapeutic intervention …

During cancer initiation and progression, the somatic epigenome is broadly reprogrammed.
This reprogramming can be a consequence of several processes, including altered …

The epigenetic regulation of immune response involves reversible and heritable changes
that do not alter the DNA sequence. Though there have been extensive studies …

Cancer cells employ a number of mechanisms to escape immunosurveillance and facilitate
tumour progression. The recent explosion of interest in immunotherapy, especially immune …