Understanding molecular mechanisms regulating angiogenesis may lead to novel therapies
for ischemic disorders. Hypoxia-inducible factor 1 (HIF-1) activates vascular endothelial …

Hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of vascular endothelial
growth factor (VEGF) and other hypoxia-responsive genes. Transgenic expression of a …

Abstract Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding
angiogenic growth factors, which are secreted by hypoxic cells and stimulate endothelial …

Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in
ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified …

The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues,
and organs. Under extended exposure to reduced oxygen levels, cells are able to survive …

Hypoxia-inducible factor-1 (HIF-1) regulates the transcription of many genes induced by low
oxygen conditions. Recent studies have demonstrated that non-hypoxic stimuli can also …

Exposure of endothelial cells to hypoxia-induced angiopoietin-2 (Ang2) expression. The
increase in Ang2 mRNA levels occurred by transcriptional regulation and by post …

Expression of vascular endothelial growth factor (VEGF) is induced in cells exposed to
hypoxia or ischemia. Neovascularization stimulated by VEGF occurs in several important …

Hypoxia is an essential pathophysiologic component of ischemic cardiovascular disease. A
better understanding of the molecular mechanisms underlying adaptive responses to …

Hypoxia inducible factor‐1α (HIF‐1α) is a key determinant of oxygen‐dependent gene
regulation in angiogenesis. HIF‐1α overexpression may be beneficial in cell therapy of …