In the Western world, cardiovascular disease, along with diabetes mellitus and its
complications, are leading causes of death. A number of important risk factors have been …

Accumulating evidence suggests that insults occurring during the perinatal period alter the
developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes …

Each differentiated cell type has its own epigenetic signature, which reflects its genotype,
developmental history, and environmental influences, and is ultimately reflected in the …

It has been approximately 30 years since the seminal discoveries of David Barker and his
colleagues, and research is beginning to unravel the mechanisms that underlie …

The global pandemic of obesity and type 2 diabetes is often causally linked to marked
changes in diet and lifestyle; namely marked increases in dietary intakes of high energy …

Fetal metabolic programming caused by the adverse intrauterine environment can induce
metabolic syndrome in adult offspring. Adverse intrauterine environment introduces fetal …

Extensive epidemiological and experimental evidence have shown that exposure to an
adverse intrauterine environment as observed in offspring of pregnancies complicated by …

Parental health or exposures can affect the lifetime health outcomes of offspring,
independently of inherited genotypes. Such 'epigenetic'effects occur over a broad range of …

Fetal programming of metabolic diseases is now a well established concept. The scope of
the Developmental Origins of Health and Disease has, however, widened and led to the …

Developmental origins of health and disease (DOHaD) is the study of how the early life
environment can impact the risk of chronic diseases from childhood to adulthood and the …