Perinatal maternal undernutrition programs the offspring hypothalamo–pituitary–adrenal (HPA) axis

J Lesage, N Sebaai, M Leonhardt, I Dutriez-Casteloot… - Stress, 2006 - Taylor & Francis
There is now compelling evidence, coming both from animal and human studies that an
early exposure to undernutrition is frequently associated with low birth weight and programs …

Perinatal environment and its influences on metabolic programming of offspring

KLK Tamashiro, TH Moran - Physiology & behavior, 2010 - Elsevier
The intrauterine environment supports the development and health of offspring.
Perturbations to this environment can have detrimental effects on the fetus that have …

Incorporating epigenetic mechanisms to advance fetal programming theories

E Conradt, DE Adkins, SE Crowell, KL Raby… - Development and …, 2018 - cambridge.org
Decades of fetal programming research indicates that we may be able to map the origins of
many physical, psychological, and medical variations and morbidities before the birth of the …

Impact of prenatal stress on neuroendocrine programming

O Viltart, CCA Vanbesien-Mailliot - The Scientific World Journal, 2007 - Wiley Online Library
Since life emerged on the Earth, the development of efficient strategies to cope with sudden
and/or permanent changes of the environment has been virtually the unique goal pursued …

[HTML][HTML] A common cause for a common phenotype: the gatekeeper hypothesis in fetal programming

S McMullen, SC Langley-Evans, L Gambling, C Lang… - Medical hypotheses, 2012 - Elsevier
Sub-optimal nutrition during pregnancy has been shown to have long-term effects on the
health of offspring in both humans and animals. The most common outcomes of such …

[HTML][HTML] Epigenetic origins of metabolic disease: the impact of the maternal condition to the offspring epigenome and later health consequences

RC Laker, ME Wlodek, JJ Connelly, Z Yan - Food Science and Human …, 2013 - Elsevier
It has long been established that an adverse maternal condition impacts on the developing
fetus and predisposes the offspring to develop metabolic and cardiovascular disease in later …

Paternal programming of offspring cardiometabolic diseases in later life

J Li, O Tsuprykov, X Yang, B Hocher - Journal of hypertension, 2016 - journals.lww.com
Early–intrauterine–environmental factors are linked to the development of cardiovascular
disease in later life. Traditionally, these factors are considered to be maternal factors such as …

[HTML][HTML] Development, epigenetics and metabolic programming

KM Godfrey, P Costello, K Lillycrop - Nestle Nutrition Institute …, 2016 - ncbi.nlm.nih.gov
It is now widely recognised that the environment in early life can have important effects on
human growth and development, including the “programming” of far reaching effects on the …

Impact of oxidative stress in fetal programming

LP Thompson, Y Al-Hasan - Journal of pregnancy, 2012 - Wiley Online Library
Intrauterine stress induces increased risk of adult disease through fetal programming
mechanisms. Oxidative stress can be generated by several conditions, such as, prenatal …

Do intrauterine or genetic influences explain the foetal origins of chronic disease? A novel experimental method for disentangling effects

A Thapar, G Harold, F Rice, XJ Ge, J Boivin… - BMC Medical Research …, 2007 - Springer
Background There is much evidence to suggest that risk for common clinical disorders
begins in foetal life. Exposure to environmental risk factors however is often not random …