There are many instances in life when the environment plays a critical role in the health
outcomes of an individual, yet none more so than those experienced in fetal and neonatal …

The early embryo and periconceptional period is a window during which environmental
factors may cause permanent change in the pattern and characteristics of development …

Introduction: The developmental origins of disease or fetal programming model predicts that
intrauterine exposures have life long consequences for physical and psychological health …

Our efforts to understand the developmental origins of birth defects and disease have
primarily focused on maternal exposures and intrauterine stressors. Recently, research into …

The ability of environmental factors to promote a phenotype or disease state not only in the
individual exposed but also in subsequent progeny for successive generations is termed …

Similar to environmental factors, EDCs (endocrine-disrupting chemicals) can influence gene
expression without modifying the DNA sequence. It is commonly accepted that the …

Background: Epigenetic mechanisms provide one potential explanation for how
environmental influences in early life cause long-term changes in chronic disease …

Complex diseases arise from a combination of heritable and environmental factors. The
contribution made by environmental factors may be mediated through epigenetics …

Development in utero is now recognized as crucial to determining later life disease
susceptibility. Whilst mechanisms are poorly understood, there has been considerable …

There is accumulating evidence that many chronic diseases such as type 2 diabetes and
coronary heart disease might originate during early life. This evidence gives rise to the …