The epigenome undergoes significant remodeling during tissue and organ development,
which coincides with a period of exquisite sensitivity to environmental exposures. In the case …

Although the field of genetics has grown by leaps and bounds within the last decade due to
the completion and availability of the human genome sequence, transcriptional regulation …

The idea that what we eat, feel, and experience influences our physical and mental state
and can be transmitted to our offspring and even to subsequent generations has been in the …

The term “epigenetics” has been widely used and abused (Greally, 2018) but the most
compelling definition of epigenetics is the study of changes in gene function that are …

Metabolic diseases, including type 2 diabetes mellitus (T2DM), are increasing worldwide at
an alarming rate. Epigenetic DNA modifications such as DNA methylation and histone …

The mammalian female reproductive tract develops from the Mullerian ducts which
differentiate, in a cranial to caudal direction, into oviducts, uterine horns, cervix and the …

Remodelling the methylome is a hallmark of mammalian development and cell
differentiation. However, current knowledge of DNA methylation dynamics in human tissue …

Obesity is a leading risk factor for impaired glucose tolerance and type 2 diabetes (T2D).
Although the cause of the obesity epidemic is multi-factorial and not entirely clear, the recent …

The traditional view that gene and environment interactions control disease susceptibility
can now be expanded to include epigenetic reprogramming as a key determinant of origins …

The DAX-1 gene encodes an unusual member of the nuclear hormone receptor superfamily.
Mutations in the human DAX-1 gene cause X-linked adrenal hypoplasia congenita …