Significance: Epidemiological and animal studies have demonstrated a close link between
maternal nutrition and chronic metabolic disease in children and adults. Compelling …

The evolution process includes genetic alterations that started with prokaryotes and now
continues in humans. A distinct difference between prokaryotic chromosomes and …

While the eukaryotic genome is the same throughout all somatic cells in an organism, there
are specific structures and functions that discern one type of cell from another. These …

The dynamic exchange of histone lysine methylation status by histone methyltransferases
and demethylases has been previously implicated as an important factor in chromatin …

Background Infant birth weight is a complex quantitative trait associated with both neonatal
and long-term health outcomes. Numerous studies have been published in which candidate …

Epigenetic modifications represent mechanisms by which cells may effectively translate
multiple signaling inputs into phenotypic outputs. Recent research is revealing that redox …

Epigenetic control of gene expression programs is essential for normal organismal
development and cellular function. Abrogation of epigenetic regulation is seen in many …

Exposure to endocrine disrupting chemicals (EDCs) is associated with dysfunctions of
metabolism, energy balance, thyroid function and reproduction, and an increased risk of …

Most human diseases are related in some way to the loss or gain in gene functions.
Regulation of gene expression is a complex process. In addition to genetic mechanisms …

The environment encountered in fetal and neonatal life exerts a profound influence on
physiological function and risk of disease in adult life. Epidemiological evidence suggests …