Endocrine disruptors are critical environmental exposures that influence health and can
promote epigenetic transgenerational inheritance of disease and abnormal physiology …

Under-and over-nutrition during pregnancy has been linked to the later development of
diseases such as diabetes and obesity. Epigenetic modifications may be one mechanism by …

In the last decades, the developmental origins of health and disease (DOHaD) have
emerged as a vigorous field combining experimental, clinical, epidemiological and public …

Cellular commitment to a specific lineage is controlled by differential silencing of genes,
which in turn depends on epigenetic processes such as DNA methylation and histone …

While the eukaryotic genome is the same throughout all somatic cells in an organism, there
are specific structures and functions that discern one type of cell from another. These …

The dynamic exchange of histone lysine methylation status by histone methyltransferases
and demethylases has been previously implicated as an important factor in chromatin …

In recent years, translational research involving humans and animals has uncovered
biological and physiological pathways that explain associations between early adverse …

Background Infant birth weight is a complex quantitative trait associated with both neonatal
and long-term health outcomes. Numerous studies have been published in which candidate …

Epigenetic modifications represent mechanisms by which cells may effectively translate
multiple signaling inputs into phenotypic outputs. Recent research is revealing that redox …

Epigenetic control of gene expression programs is essential for normal organismal
development and cellular function. Abrogation of epigenetic regulation is seen in many …