Highlights•C. neoformans possesses high-affinity and low-affinity iron uptake systems.•The
reductive high-affinity iron uptake system is required for virulence.•The regulation of iron …

Transcriptional Regulatory Map of Iron Homeostasis Reveals a New Control Circuit for
Capsule Formation in Cryptococcus neoformans | Genetics | Oxford Academic Skip to Main …

Vertebrate hosts actively sequester iron, and fungal and other pathogens must therefore
adapt to a severe limitation in iron availability to cause disease. Recent studies reveal that …

The acquisition of iron from mammalian hosts is an important aspect of infection because
microbes must compete with the host for this nutrient and iron perception often regulates …

The level of available iron in the mammalian host is extremely low, and pathogenic microbes
must compete with host proteins such as transferrin for iron. Iron regulation of gene …

Iron acquisition is critical for the ability of the pathogenic yeast Cryptococcus neoformans to
cause disease in vertebrate hosts. In particular, iron overload exacerbates cryptococcal …

Iron, copper, and zinc are essential for all living organisms. Moreover, the homeostasis of
these metals is vital to microorganisms during pathogenic interactions with a host. Most …

Iron plays a key role in host-pathogen interactions. Microbial pathogens require iron for
survival and virulence, whereas mammalian hosts sequester and withhold iron as a means …

Iron acquisition is a critical aspect of the virulence of many pathogenic microbes, and iron
limitation is an important defense mechanism for mammalian hosts. We are examining …

Ferritin, a major iron storage protein in vertebrates, supplies iron upon iron deficiency.
Ferritin is also found extracellularly, and acts as an iron carrier and a contributor to the …