Gene MAGEA1 belongs to a group of human germline-specific genes that rely on DNA
methylation for repression in somatic tissues. Many of these genes, termed cancer-germline …

Several human germline-specific genes rely principally on DNA methylation for repression
in somatic tissues. Many of these genes, including MAGEA1, were qualified as cancer …

Tumor development involves alterations in DNA methylation patterns, which include both
gains (hypermethylation) and losses (hypomethylation) in different genomic regions. The …

The broad range of expression of cancer-testis antigens in various tumor types makes the
proteins encoded by human MAGE gene family promising targets for anticancer …

MAGEA11 is a cancer germline (CG) antigen and androgen receptor co-activator. Its
expression in cancers other than prostate, and its mechanism of activation, has not been …

Several male germ line-specific genes, including MAGE-A1, rely on DNA methylation for
their repression in normal somatic tissues. These genes become activated in many types of …

Human tumor development is often associated with a DNA demethylation process. This
results in the activation of germline-specific genes, such as MAGE-A1, which rely on DNA …

Background Many human tumors show aberrant activation of a group of germline-specific
genes, termed cancer-germline (CG) genes, several of which appear to exert oncogenic …

Global loss of DNA methylation is frequently observed in the genome of human tumors.
Although this epigenetic alteration is clearly associated with cancer progression, the way it …

The MAGE‐1 gene, expressed in some tumors of different histological origins, codes for a
tumor antigen recognized by cytotoxic T lymphocytes. The gene is not expressed in normal …