Genome‐wide DNA methylation profile analysis in thoracic ossification of the ligamentum flavum
T Fan, X Meng, C Sun, X Yang, G Chen… - Journal of Cellular …, 2020 - Wiley Online Library
Thoracic ossification of the ligamentum flavum (TOLF) causes serious spinal canal stenosis.
The underlying aetiology may relate to genetic and inflammatory factors. DNA methylation …
The underlying aetiology may relate to genetic and inflammatory factors. DNA methylation …
Identification of the molecular mechanism and diagnostic biomarkers in the thoracic ossification of the ligamentum flavum using metabolomics and transcriptomics
J Li, L Yu, S Guo, Y Zhao - BMC Molecular and Cell Biology, 2020 - Springer
Background To establish a metabolite fingerprint of ossification of the thoracic ligamentum
flavum (OTLF) patients using liquid chromatography-mass spectrometry (LC-MS) in …
flavum (OTLF) patients using liquid chromatography-mass spectrometry (LC-MS) in …
iTRAQ quantitative proteomic study in patients with thoracic ossification of the ligamentum flavum
B Wang, Z Chen, X Meng, M Li, X Yang… - … and biophysical research …, 2017 - Elsevier
Thoracic ossification of the ligamentum flavum (TOLF) is a unique disease with ectopic
ossification, and is a major cause of thoracic spinal stenosis and myelopathy. However, the …
ossification, and is a major cause of thoracic spinal stenosis and myelopathy. However, the …
A transcriptome-level study identifies changing expression profiles for ossification of the ligamentum flavum of the spine
Y Han, Y Hong, L Li, T Li, Z Zhang, J Wang… - … Therapy-Nucleic Acids, 2018 - cell.com
Ossification of the ligamentum flavum (OLF) is a common spinal disorder that causes
myelopathy and radiculopathy. Non-coding RNAs (ncRNAs) are involved in numerous …
myelopathy and radiculopathy. Non-coding RNAs (ncRNAs) are involved in numerous …
LGR5 regulates osteogenic differentiation of human thoracic ligamentum flavum cells by Wnt signalling pathway
X Yang, C Sun, X Meng, G Chen, T Fan… - Journal of Cellular …, 2022 - Wiley Online Library
Thoracic ossification of the ligamentum flavum (TOLF) is ectopic ossification of the spinal
ligaments. Histologically, the development of TOLF can be described as the process of …
ligaments. Histologically, the development of TOLF can be described as the process of …
Identification of crucial miRNAs and lncRNAs for ossification of ligamentum flavum
D Kong, Q Zhao, W Liu, F Wang - Molecular medicine …, 2019 - spandidos-publications.com
The present study aimed to screen crucial micro (mi) RNAs and long non‑coding (lnc) RNAs
involved in the development of ossification of ligamentum flavum (OLF) based on the miRNA …
involved in the development of ossification of ligamentum flavum (OLF) based on the miRNA …
Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration
Background Environmental and endogenous factors under genetic predisposition are
considered to initiate the human intervertebral disc (IVD) degeneration. DNA methylation is …
considered to initiate the human intervertebral disc (IVD) degeneration. DNA methylation is …
The involvement and possible mechanism of pro-inflammatory tumor necrosis factor alpha (TNF-α) in thoracic ossification of the ligamentum flavum
C Zhang, Z Chen, X Meng, M Li, L Zhang, A Huang - PloS one, 2017 - journals.plos.org
Thoracic ossification of the ligamentum flavum (TOLF) is characterized by ectopic bone
formation in the ligamentum flavum and is considered to be a leading cause of thoracic …
formation in the ligamentum flavum and is considered to be a leading cause of thoracic …
Identification of abnormally methylated–differentially expressed genes and pathways in osteoarthritis: a comprehensive bioinformatic study
L Zheng, W Chen, G Xian, B Pan, Y Ye, M Gu… - Clinical …, 2021 - Springer
Objectives To investigate abnormally methylated–differentially expressed genes (DEGs) and
their related pathways in osteoarthritis (OA) by comprehensive bioinformatic analysis …
their related pathways in osteoarthritis (OA) by comprehensive bioinformatic analysis …
Integrating bioinformatic strategies with real-world data to infer distinctive immunocyte infiltration landscape and immunologically relevant transcriptome fingerprints in …
B Zhang, G Chen, X Chen, X Yang, T Fan… - Journal of …, 2021 - Taylor & Francis
Purpose Ossification of the ligamentum flavum (OLF) is a multifactorial disease
characterized by an insidious and debilitating process of abnormal bone formation in …
characterized by an insidious and debilitating process of abnormal bone formation in …
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