DNA methyltransferases
TH Bestor, GL Verdine - Current opinion in cell biology, 1994 - Elsevier
Mammals have long been known to tag their DNA by the addition of methyl groups to
cytosine residues. Only quite recently, however, has the functional significance of DNA …
cytosine residues. Only quite recently, however, has the functional significance of DNA …
Cloning of a mammalian DNA methyltransferase
TH Bester - Gene, 1988 - Elsevier
Cloning and sequencing of cDNA clones has shown that mammalian DNA (cytosine-5)-
methyltransferase comprises a 1000-amino acid (aa) N-terminal region of unknown function …
methyltransferase comprises a 1000-amino acid (aa) N-terminal region of unknown function …
DNA demethylation
AP Wolffe, PL Jones, PA Wade - Proceedings of the …, 1999 - National Acad Sciences
Cytosine 5! methylation of CpG dinucleotides within and around genes exerts a major
influence on transcription in many plants and animals (1–3). DNA methylation can be causal …
influence on transcription in many plants and animals (1–3). DNA methylation can be causal …
Eukaryotic cytosine methyltransferases
▪ Abstract Large-genome eukaryotes use heritable cytosine methylation to silence
promoters, especially those associated with transposons and imprinted genes. Cytosine …
promoters, especially those associated with transposons and imprinted genes. Cytosine …
Murine DNA Cytosine-C5 Methyltransferase: Pre-Steady- and Steady-State Kinetic Analysis with Regulatory DNA Sequences
J Flynn, JF Glickman, NO Reich - Biochemistry, 1996 - ACS Publications
We present the first description of K mDNA, K dDNA, k cat, and k methylation for a
mammalian DNA methyltransferase. Homogeneous, 190 000 M r DNA (cytosine-5-) …
mammalian DNA methyltransferase. Homogeneous, 190 000 M r DNA (cytosine-5-) …
Structure and function of eukaryotic DNA methyltransferases
T Chen, E Li - Current topics in developmental biology, 2004 - Elsevier
DNA methylation is a common epigenetic modification found in eukaryotic organisms
ranging from fungi to mammals. Over the past 15 years, a number of eukaryotic DNA …
ranging from fungi to mammals. Over the past 15 years, a number of eukaryotic DNA …
[HTML][HTML] DNA (cytosine-5)-methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe
The mechanisms that establish and maintain methylation patterns in the mammalian
genome are very poorly understood, even though perturbations of methylation patterns lead …
genome are very poorly understood, even though perturbations of methylation patterns lead …
Mammalian DNA (cytosine-5) methyltransferases and their expression
S Pradhan, PO Esteve - Clinical Immunology, 2003 - Elsevier
Two classes of functional DNA (cytosine-5) methyltransferases have been discovered in
mammals to date. One class methylates the unmodified DNA and is designated as the de …
mammals to date. One class methylates the unmodified DNA and is designated as the de …
Eukaryotic DNA methylation as an evolutionary device
V Colot, JL Rossignol - Bioessays, 1999 - Wiley Online Library
DNA methylation is catalyzed by a family of conserved DNA methyltransferases and is
widespread among protists, plants, fungi and animals. It is however absent in some species …
widespread among protists, plants, fungi and animals. It is however absent in some species …
The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites
A Hermann, R Goyal, A Jeltsch - Journal of Biological Chemistry, 2004 - ASBMB
In the cell, Dnmt1 is the major enzyme in maintenance of the pattern of DNA methylation
after DNA replication. Evidence suggests that the protein is located at the replication fork …
after DNA replication. Evidence suggests that the protein is located at the replication fork …