Mammals have long been known to tag their DNA by the addition of methyl groups to
cytosine residues. Only quite recently, however, has the functional significance of DNA …

Cloning and sequencing of cDNA clones has shown that mammalian DNA (cytosine-5)-
methyltransferase comprises a 1000-amino acid (aa) N-terminal region of unknown function …

Cytosine 5! methylation of CpG dinucleotides within and around genes exerts a major
influence on transcription in many plants and animals (1–3). DNA methylation can be causal …

▪ Abstract Large-genome eukaryotes use heritable cytosine methylation to silence
promoters, especially those associated with transposons and imprinted genes. Cytosine …

We present the first description of K mDNA, K dDNA, k cat, and k methylation for a
mammalian DNA methyltransferase. Homogeneous, 190 000 M r DNA (cytosine-5-) …

DNA methylation is a common epigenetic modification found in eukaryotic organisms
ranging from fungi to mammals. Over the past 15 years, a number of eukaryotic DNA …

The mechanisms that establish and maintain methylation patterns in the mammalian
genome are very poorly understood, even though perturbations of methylation patterns lead …

Two classes of functional DNA (cytosine-5) methyltransferases have been discovered in
mammals to date. One class methylates the unmodified DNA and is designated as the de …

DNA methylation is catalyzed by a family of conserved DNA methyltransferases and is
widespread among protists, plants, fungi and animals. It is however absent in some species …

In the cell, Dnmt1 is the major enzyme in maintenance of the pattern of DNA methylation
after DNA replication. Evidence suggests that the protein is located at the replication fork …