Background DNA methylation is an epigenetic mark that balances plasticity with stability.
While DNA methylation exhibits tissue specificity, it can also vary with age and potentially …

Tissue differences are one of the largest contributors to variability in the human DNA
methylome. Despite the tissue-specific nature of DNA methylation, the inaccessibility of …

DNA methylation is known to be associated with cell differentiation, aging, disease and
cancer. There exists an expanding base of knowledge regarding tissue-specific DNA …

The possibility that alterations in DNA methylation are mechanistic drivers of development,
aging and susceptibility to disease is widely acknowledged, but evidence remains patchy or …

Differential DNA methylation in the brain is associated with many psychiatric diseases, but
access to brain tissues is essentially limited to postmortem samples. The use of surrogate …

Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …

Alzheimer's disease (AD) is the most common cause of dementia with advancing age as its
strongest risk factor. AD neuropathologic change (ADNC) is known to be associated with …

DNA methylation plays an important role in development of disease and the process of
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …

Age-associated DNA methylation changes have been widely reported across many different
tissue and cell types. Epigenetic 'clocks' that can predict chronological age with a …

Background Several recent studies reported aging effects on DNA methylation levels of
individual CpG dinucleotides. But it is not yet known whether aging-related consensus …