The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation
JJ Talbot, X Song, X Wang, MM Rinschen… - Journal of the …, 2014 - journals.lww.com
Abstract Polycystin-1 (PC1) mutations result in proliferative renal cyst growth and
progression to renal failure in autosomal dominant polycystic kidney disease (ADPKD). The …
progression to renal failure in autosomal dominant polycystic kidney disease (ADPKD). The …
Polycystin-1 regulates STAT activity by a dual mechanism
JJ Talbot, JM Shillingford, S Vasanth… - Proceedings of the …, 2011 - National Acad Sciences
Mutations in polycystin-1 (PC1) lead to autosomal-dominant polycystic kidney disease
(ADPKD), a leading cause of renal failure for which no treatment is available. PC1 is an …
(ADPKD), a leading cause of renal failure for which no treatment is available. PC1 is an …
Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease
EE Olsan, S Mukherjee… - Proceedings of the …, 2011 - National Acad Sciences
Autosomal-dominant (AD) polycystic kidney disease (PKD) is a leading cause of renal
failure in the United States, and currently lacks available treatment options to slow disease …
failure in the United States, and currently lacks available treatment options to slow disease …
Regulation of STATs by polycystin-1 and their role in polycystic kidney disease
Autosomal-dominant polycystic kidney disease (ADPKD) is a common genetic disease
caused by mutations in the gene coding for polycystin-1 (PC1). PC1 can regulate STAT …
caused by mutations in the gene coding for polycystin-1 (PC1). PC1 can regulate STAT …
Identification of targets of IL-13 and STAT6 signaling in polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is a life-threatening, highly
prevalent monogenic disease caused by mutations in polycystin-1 (PC1) in 85% of patients …
prevalent monogenic disease caused by mutations in polycystin-1 (PC1) in 85% of patients …
Inactivation of integrin-β1 prevents the development of polycystic kidney disease after the loss of polycystin-1
K Lee, S Boctor, LMC Barisoni… - Journal of the American …, 2015 - journals.lww.com
Abstract Dysregulation of polycystin-1 (PC1) leads to autosomal dominant polycystic kidney
disease (ADPKD), a disorder characterized by the formation of multiple bilateral renal cysts …
disease (ADPKD), a disorder characterized by the formation of multiple bilateral renal cysts …
STAT signaling in polycystic kidney disease
The most common form of polycystic kidney disease (PKD) in humans is caused by
mutations in the PKD1 gene coding for polycystin1 (PC1). Among the many identified or …
mutations in the PKD1 gene coding for polycystin1 (PC1). Among the many identified or …
STAT3 signaling in polycystic kidney disease
T Weimbs, JJ Talbot - Drug Discovery Today: Disease Mechanisms, 2013 - Elsevier
Mutations in the gene coding for the integral membrane protein polycystin-1 (PC1) are the
cause of most cases of autosomal-dominant polycystic kidney disease (ADPKD), a very …
cause of most cases of autosomal-dominant polycystic kidney disease (ADPKD), a very …
Emerging evidence of a link between the polycystins and the mTOR pathways
A Boletta - Pathogenetics, 2009 - Springer
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease characterized
by the formation of renal cysts. This disease can be caused by mutations in two genes …
by the formation of renal cysts. This disease can be caused by mutations in two genes …
Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression …
KN Felekkis, P Koupepidou, E Kastanos, R Witzgall… - BMC nephrology, 2008 - Springer
Abstract Background Autosomal Dominant Polycystic Kidney Disease (ADPKD) is
characterized by the formation of multiple fluid-filled cysts that destroy the kidney …
characterized by the formation of multiple fluid-filled cysts that destroy the kidney …