The human colon cancer methylome shows similar hypo-and hypermethylation at conserved tissue-specific CpG island shores
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur
in cancer, including hypomethylation of oncogenes and hypermethylation of tumor …
in cancer, including hypomethylation of oncogenes and hypermethylation of tumor …
[HTML][HTML] Genome-wide methylation analysis of human colon cancer reveals similar hypo-and hypermethylation at conserved tissue-specific CpG island shores
Alterations in DNA methylation (DNAm) in cancer have been known for 25 years, including
hypomethylation of oncogenes and hypermethylation of tumor suppressor genes 1 …
hypomethylation of oncogenes and hypermethylation of tumor suppressor genes 1 …
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains
Extensive changes in DNA methylation are common in cancer and may contribute to
oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale …
oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale …
Evidence for an instructive mechanism of de novo methylation in cancer cells
I Keshet, Y Schlesinger, S Farkash, E Rand, M Hecht… - Nature …, 2006 - nature.com
DNA methylation has a role in the regulation of gene expression during normal mammalian
development but can also mediate epigenetic silencing of CpG island genes in cancer and …
development but can also mediate epigenetic silencing of CpG island genes in cancer and …
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
M Weber, JJ Davies, D Wittig, EJ Oakeley, M Haase… - Nature …, 2005 - nature.com
Cytosine methylation is required for mammalian development and is often perturbed in
human cancer. To determine how this epigenetic modification is distributed in the genomes …
human cancer. To determine how this epigenetic modification is distributed in the genomes …
Increased methylation variation in epigenetic domains across cancer types
Tumor heterogeneity is a major barrier to effective cancer diagnosis and treatment. We
recently identified cancer-specific differentially DNA-methylated regions (cDMRs) in colon …
recently identified cancer-specific differentially DNA-methylated regions (cDMRs) in colon …
Predicting aberrant CpG island methylation
Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is
one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of …
one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of …
Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies
DJ Smiraglia, LJ Rush, MC Frühwald… - Human molecular …, 2001 - academic.oup.com
Cancer cell lines are widely used in many types of cancer research, including studies aimed
at understanding DNA hypermethylation of gene promoters in cancer. Hypermethylation of …
at understanding DNA hypermethylation of gene promoters in cancer. Hypermethylation of …
DNA methylation differences associated with tumor tissues identified by genome scanning analysis
Most investigations on the role of DNA methylation in cancer have focused on epigenetic
changes associated with known tumor suppressor genes. This may have led to an …
changes associated with known tumor suppressor genes. This may have led to an …
Identification of driver and passenger DNA methylation in cancer by epigenomic analysis
S Kalari, GP Pfeifer - Advances in genetics, 2010 - Elsevier
Human cancer genomes are characterized by widespread aberrations in DNA methylation
patterns including DNA hypomethylation of mostly repetitive sequences and …
patterns including DNA hypomethylation of mostly repetitive sequences and …