The view that autosomal gene expression is controlled exclusively by protein trans-acting
factors has been challenged recently by the identification of RNA molecules that regulate …

DNA methylation is important in the control of gene transcription and chromatin structure.
The complexities of this process are just beginning to be elucidated in relationship to other …

Histone methylation has important roles in regulating transcription, genome integrity and
epigenetic inheritance. Historically, methylated histone arginine and lysine residues have …

The regulation of gene transcription is not simply dependent on the presence or absence of
DNA-binding transcription factors that turn genes on or off, but also involves processes …

Modifications of both DNA and chromatin can affect gene expression and lead to gene
silencing. Evidence of links between DNA methylation and histone hypoacetylation is …

Recent studies demonstrated that histone methylation is not static but is dynamically
regulated by histone methyltransferases and the newly discovered histone demethylases …

For decades, chromatin was considered to be an inert structure whose only role was the
compacting and confining of DNA inside the eukaryotic nucleus. However, tremendous …

The field of epigenetics has recently moved to the forefront of studies relating to diverse
processes such as transcriptional regulation, chromatin structure, genome integrity, and …

Over three decades ago DNA methylation had been suggested to play a role in the
regulation of gene expression. This chapter reviews the development of this field of research …

DNA methylation has an essential regulatory function in mammalian development, serving
to repress nontranscribed genes stably in differentiated adult somatic cells. Recent data …