DNA methylation, histone deacetylation, and methylation of histone H3 at lysine 9 are the
three best-characterized covalent modifications associated with a repressed chromatin state …

Epigenetic regulation is the mechanism by which gene function is selectively activated or
inactivated in the cells. It provides higher-ordered and more specified genetic information …

One of the most critical epigenetic signatures present in the genome of higher eukaryotes is
the methylation of DNA at the C-5 position of the cytosine ring. Based on the sites of DNA …

The importance of histone methylation in gene regulation was suggested over 40 years ago.
Yet, the dynamic nature of this histone modification was recognized only recently, with the …

Silencing of tumor-suppressor genes by hypermethylation of promoter CpG islands is well
documented in human cancer and may be mediated by methyl-CpG-binding proteins, like …

Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

Methylation of histones mediates transcriptional silencing at heterochromatin sites and
affects regulated transcription at euchromatic loci. So is the methyl group a permanent mark …

Differentiation-related DNA methylation is receiving increasing attention, partly owing to
new, whole-genome analyses. These revealed that cell type-specific differential methylation …

Methylation of cytosines is the key epigenetic modification of DNA in eukaryotes and is
associated with a repressed chromatin state and inhibition of gene expression. The …

Post-translational addition of methyl groups to the amino-terminal tails of histone proteins
was discovered more than three decades ago. Only now, however, is the biological …