DNA methylation represents a fundamental epigenetic modification that regulates chromatin
architecture and gene transcription. Many diseases, including cancer, show aberrant …

It has been nearly 40 y since it was suggested that genomic methylation patterns could be
transmitted via maintenance methylation during S phase and might play a role in the …

We have developed a strategy to introduce in vitro-methylated DNA into defined
chromosomal locations. Using this system, we examined the effects of methylation on …

Research in cancer epigenomics is driven by the development of novel technologies and
the utilization of model organisms ranging from yeasts to plants to vertebrates. For decades …

). It may also contribute to immobilization of mammalian transposons, suppression of
transcriptional noise, and the control of tissue-specific gene expression, but decisive …

The prevailing views as to the form, function, and regulation of genomic methylation patterns
have their origin many years in the past, at a time when the structure of the mammalian …

Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …

A correlation between DNA methylation and transcriptional silencing has existed for many
years. Recently, substantial progress has been reported in the search for proteins that …

LSH, a protein related to the SNF2 family of chromatin-remodeling ATPases, is required for
efficient DNA methylation in mammals. How LSH functions to support DNA methylation and …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …