BACKGROUND. The tumor immune response is increasingly associated with better clinical
outcomes in breast and other cancers. However, the evaluation of tumor-infiltrating …

Purpose Epigenetic alterations measured in blood may help guide breast cancer treatment.
The multisite prospective study TBCRC 005 was conducted to examine the ability of a novel …

Background Immune surveillance acts as a defense mechanism in cancer, and its disruption
is involved in cancer progression. DNA methylation reflects the phenotypic identity of cells …

Background Tumor-infiltrating lymphocytes (TILs), especially CD8+ TILs, can be used for
predicting immunotherapy responsiveness and survival outcome. However, the evaluation …

Cancer is the second leading cause of death worldwide being responsible for 9.6 million
deaths in 2018. Epigenetic alterations are key in directing the aberrant expression of tumor …

Simple Summary Tumor-infiltrating lymphocytes (TILs) are immune cells that can be
involved in the anti-tumor response and are presently viewed as a promising, inexpensive …

DNA methylation plays a critical role in the regulation of gene expression, differentiation and
in the development of cancer and other diseases. Hypermethylation of CpG islands located …

Abstract Changes in DNA methylation in cancer have been heralded as promising targets
for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite …

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …

In light of the high incidence and mortality rates of cancer, early and accurate diagnosis is an
important priority for assigning optimal treatment for each individual with suspected illness …