Polycystic kidney disease is the most common heritable disease in humans. In addition to
epithelial cysts in the kidney, liver and pancreas, patients with autosomal dominant …

Polycystic kidney disease (PKD) is a disease of the nephron, characterized by the formation
of multiple renal tubular cysts, leading to endstage renal failure. The most common form is …

Mutations in the PKD1 gene are responsible for> 85% of autosomal dominant polycystic
kidney disease (ADPKD). The protein product of PKD1, polycystin-1, is a large, modular …

This short review summarizes some information concerning what is known about matrix
adhesion molecules, focal adhesion proteins, and cell-cell adhesion molecules in normal …

The 14 kb mRNA of the polycystic kidney disease gene PKD1 encodes a novel large (~ 460
kDa) protein, polycystin-1, of unknown function that is responsible for autosomal dominant …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common renal
monogenic disorder. It is characterized by progressive, bilateral renal cystic expansion …

Abstract Background Polycystin-1 (PC-1) is a large plasma membrane receptor, encoded by
the PKD1 gene, which is mutated in most cases of Autosomal Dominant Polycystic Kidney …

The PKD1 protein, polycystin-1, is a large transmembrane protein of uncertain function and
topology. To study the putative functions of polycystin-1, conditionally immortalized kidney …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or
PKD2, the genes encoding polycystin 1 (PC1) and polycystin 2 (PC2), respectively. PC1 and …

Polycystin-1 (PC-1) is a large plasma-membrane receptor encoded by the PKD1 gene
mutated in autosomal dominant polycystic kidney disease (ADPKD). Although the disease is …