DNA methylation is assumed to be complementary on both alleles across the genome,
although there are exceptions, notably in regions subject to genomic imprinting. We present …

Changes in DNA methylation are involved in development, disease, and the response to
environmental conditions. However, not all regulatory elements are functionally methylation …

DNA methylation is an essential epigenetic mark whose role in gene regulation and its
dependency on genomic sequence and environment are not fully understood. In this study …

DNA methylation is the most stable type of epigenetic modification modulating the
transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report …

DNA methylation is one of several epigenetic mechanisms that contribute to the regulation of
gene expression; however, the extent to which methylation of CpG dinucleotides correlates …

CpG islands (CGIs) are dense clusters of CpG sequences that punctuate the CpG-deficient
human genome and associate with many gene promoters. As CGIs also differ from bulk …

Peripheral mononuclear cell preparations are commonly used as proxies for other tissues in
studies of the role of gene expression and methylation in human disease. Whether changes …

Background Despite the important role DNA methylation plays in transcriptional regulation,
the transgenerational inheritance of DNA methylation is not well understood. The genetic …

Background Ethnic differences in human DNA methylation have been shown for a number of
CpG sites, but the genome-wide patterns and extent of these differences are largely …

Prenatal development and early childhood are critical periods for establishing the tissue-
specific epigenome, and may have a profound impact on health and disease in later life …