Cerebral aneurysm rupture is a devastating event resulting in subarachnoid hemorrhage
and is associated with significant morbidity and death. Up to 50% of individuals do not …

Animal models are necessary to develop and test innovations in aneurysm therapy before
clinical introduction. This review aims at identifying the most likely candidates for …

Animal models make an important contribution to our basic understanding of the
pathobiology of human brain aneurysms, are indispensable in testing novel treatment …

Subarachnoid hemorrhage secondary to rupture of an intracranial aneurysm is a highly
lethal medical condition. Current management strategies for unruptured intracranial …

Cerebral aneurysm is a common cerebrovascular disease that is sometimes complicated by
rupture or an enlarged mass. We are now aggressively evaluating and managing …

We have developed a mouse model of intracranial aneurysm that recapitulates key features
of human intracranial aneurysms. In this model, spontaneous aneurysmal rupture occurs …

BACKGROUND: Size and morphological features are associated with intracranial aneurysm
(IA) rupture. The cellular mechanisms of IA development and rupture are poorly known …

Subarachnoid hemorrhage resulting from intracranial aneurysms (IAs) is associated with
high rates of morbidity and mortality. Although trigger mechanisms in the pathogenesis of …

Intracranial aneurysms (IA) are characterized by weakened cerebral vessel walls that may
lead to rupture and subarachnoid hemorrhage. The mechanisms behind their formation and …

Background. Most available large animal extracranial aneurysm models feature healthy non-
degenerated aneurysm pouches with stable long-term follow-ups and extensive healing …