Understanding the cellular and molecular mechanisms underlying the formation and
maintenance of memories is a central goal of the neuroscience community. It is well …

The formation of long-term memory involves a series of molecular and cellular changes,
including gene transcription, protein synthesis and synaptic plasticity dynamics. Some of …

Although the term 'epigenetics 'was coined nearly seventy years ago, its critical function in
memory processing by the adult CNS has only recently been appreciated. The hypothesis …

Recent advances in chromatin biology have identified a role for epigenetic mechanisms in
the regulation of neuronal gene expression changes, a necessary process for proper …

The ability to form memories is a prerequisite for an organism's behavioral adaptation to
environmental changes. At the molecular level, the acquisition and maintenance of memory …

In this review we address the idea that conservation of epigenetic mechanisms for
information storage represents a unifying model in biology, with epigenetic mechanisms …

Brain-derived neurotrophic factor (bdnf) is one of numerous gene products necessary for
long-term memory formation and dysregulation of bdnf has been implicated in the …

Although the critical role for epigenetic mechanisms in development and cell differentiation
has long been appreciated, recent evidence reveals that these mechanisms are also …

This brief review focuses on the role of epigenetic mechanisms in plasticity and memory
formation, and their identification as targets of activity-dependent regulation in neurons …

Although long-lasting behavioral memories have long been thought to require equally
persistent molecular changes, little is known about the biochemical underpinnings of …