Gene-specific methylation patterns in mammals play a role in a variety of biological
processes in the embryo and adult tissues. These patterns are established during embryo …

This paper shows stage-and tissue-specific global demethylation and remethylation
occurring during embryonic development. The egg genome is strikingly undermethylated …

DNA methylation plays a role in the repression of gene expression in animal cells. In the
mouse preimplantation embryo, most genes are unmethylated but a wave of de novo …

Methylation patterns of specific genes have been studied by polymerase chain reaction and
found to undergo dynamic changes in the germ line and early embryo. Some CpG sites are …

Dynamic epigenetic modification of the genome occurs during early development of the
mouse. Active demethylation of the paternal genome occurs in the zygote, followed by …

Critical epigenetic regulation of primate embryogenesis entails DNA methylome changes.
Here we report genome-wide composition, patterning, and stage-specific dynamics of DNA …

A large number of studies have documented the methylation patterns of individual genes
and repeated sequences in different tissues of various mammalian species. This has …

In mammals, active demethylation of cytosine methylation in the sperm genome prior to
forming a functional zygotic nucleus is thought to be a function of the oocyte cytoplasm …

Active demethylation of the paternal genome but not of the maternal genome occurs in
fertilized mouse, rat, pig, and bovine zygotes. To study whether this early demethylation …

Publisher Summary This chapter discusses the deoxyribonucleic acid (DNA) methylation
from embryo to adult. The existence of tissue-specific methylation patterns and the results of …