Multigenerational epigenetic inheritance: Transmitting information across generations

NO Burton, EL Greer - Seminars in cell & developmental biology, 2022 - Elsevier
Inherited epigenetic information has been observed to regulate a variety of complex
organismal phenotypes across diverse taxa of life. This continually expanding body of …

[HTML][HTML] Molecular mechanisms of epigenetic inheritance: possible evolutionary implications

P Sarkies - Seminars in Cell & Developmental Biology, 2020 - Elsevier
Recently interest in multi-generational epigenetic phenomena have been fuelled by highly
reproducible intergenerational and transgenerational inheritance paradigms in several …

The genetics of epigenetic inheritance: modes, molecules, and mechanisms

S Schaefer, JH Nadeau - The Quarterly review of biology, 2015 - journals.uchicago.edu
Organisms adapt developmental and physiological features to local and transient conditions
in part by modulating transcription, translation, and protein functions, usually without …

Transgenerational epigenetic inheritance

A Bošković, OJ Rando - Annual review of genetics, 2018 - annualreviews.org
Inheritance of genomic DNA underlies the vast majority of biological inheritance, yet it has
been clear for decades that additional epigenetic information can be passed on to future …

Mechanisms of transgenerational epigenetic inheritance: lessons from animal model organisms

F Santilli, A Boskovic - Current Opinion in Genetics & Development, 2023 - Elsevier
Epigenetic inheritance is a phenomenon whereby stochastic or signal-induced changes to
parental germline epigenome modulate phenotypic output in one or more subsequent …

Three epigenetic information channels and their different roles in evolution

N Shea, I Pen, T Uller - Journal of evolutionary biology, 2011 - academic.oup.com
There is increasing evidence for epigenetically mediated transgenerational inheritance
across taxa. However, the evolutionary implications of such alternative mechanisms of …

Transgenerational epigenetic inheritance: how important is it?

U Grossniklaus, WG Kelly, AC Ferguson-Smith… - Nature Reviews …, 2013 - nature.com
Much attention has been given to the idea of transgenerational epigenetic inheritance, but
fundamental questions remain regarding how much takes place and the impact that this …

[HTML][HTML] Transgenerational epigenetic inheritance: myths and mechanisms

E Heard, RA Martienssen - Cell, 2014 - cell.com
Since the human genome was sequenced, the term" epigenetics" is increasingly being
associated with the hope that we are more than just the sum of our genes. Might what we …

Genetic variation and the evolution of epigenetic regulation

RE Furrow, MW Feldman - Evolution, 2014 - academic.oup.com
Epigenetic variation has been observed in a range of organisms, leading to questions of the
adaptive significance of this variation. In this study, we present a model to explore the …

Transgenerational epigenetic inheritance: more questions than answers

L Daxinger, E Whitelaw - Genome research, 2010 - genome.cshlp.org
Epigenetic modifications are widely accepted as playing a critical role in the regulation of
gene expression and thereby contributing to the determination of the phenotype of …