BACKGROUND The sperm chromatin of fertile men retains a small number of nucleosomes
that are enriched at developmental gene promoters and imprinted gene loci. This unique …

OBJECTIVE: To evaluate genome-wide DNA methylation patterns in sperm from men with
abnormal sperm chromatin packaging and patients displaying abnormal embryogenesis …

OBJECTIVE: To review and summarize the current understanding of the epigenetic status of
human sperm in regards to protamination, specific localization and modifications of retained …

STUDY QUESTION Is there a distinct sperm histone-retained epigenetic signature in
unexplained male factor infertility patients resulting in compromised blastocyst …

Along with many of the genome-wide transitions in chromatin composition throughout
spermatogenesis, epigenetic modifications on histone tails and DNA are continuously …

The classical idea about the function of the mammalian sperm chromatin is that it serves to
transmit a highly protected and transcriptionally inactive paternal genome, largely …

Recent advances, including the human genome project and numerous studies of cancer
and other diseases, have shown that the genetic code is not simply limited to the sequence …

Recent work in the field of male fertility has yielded significant increases in our
understanding of the sperm epigenome and its potential role in embryonic development …

Purpose Alternations to the paternal epigenome, specifically the components of sperm
chromatin, can lead to infertility in humans and potentially transmit aberrant information to …

The scope of paternal contributions during early embryonic development has long been
considered limited. Dramatic changes in chromatin structure throughout spermatogenesis …