Significance: The progressive, dose-dependent, and potentially reversible epigenetic
changes observed in cancer present new opportunities in cancer risk modification and …

ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …

Epidemiological, clinical, and animal studies collectively indicate that dietary folate intake
and blood folate levels are inversely associated with colorectal cancer risk. Folate plays an …

The inheritance of information based on gene expression levels is known as epigenetics, as
opposed to genetics, which refers to information transmitted on the basis of gene sequence …

Experimental studies demonstrated that maternal exposure to certain environmental and
dietary factors during early embryonic development can influence the phenotype of offspring …

Diet is a major factor in the aetiology of colorectal cancer (CRC). Epidemiological evidence
suggests that folate confers a modest protection against CRC risk. However, the relationship …

Folate is a methyl donor that plays an essential role in DNA synthesis and biological
methylation reactions, including DNA methylation. Folate deficiency may be implicated in the …

DNA methylation is one of several epigenetic mechanisms that play a regulatory role in
genome programming and imprinting during embryogenesis. Aberrant DNA methylation has …

Inappropriate diet may contribute to one third of cancer deaths. Folates, a group of water-
soluble B vitamins present in high concentrations in green, leafy vegetables, maintain DNA …

Epigenetic changes are inherited alterations in DNA that affect gene expression and
function without altering the DNA sequence. DNA methylation is one epigenetic process …