Chronic kidney disease (CKD) is strongly associated with increased cardiovascular risk.
Impaired endothelial function, a key initiating step in the pathogenesis of cardiovascular …

Patients with chronic kidney disease (CKD) have elevated circulating levels of
trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes and associated with …

Atherosclerosis is associated with various pathological manifestations, such as ischemic
heart disease, ischemic stroke, and peripheral arterial disease, and remains a leading …

Trimethylamine N-oxide (TMAO) leads to the development of cardiovascular and chronic
kidney diseases, but there are currently no potent drugs that inhibit the production or toxicity …

Trimethylamine-N-oxide (TMAO) is a product of dietary, gut microbiome, and tissues
metabolism. Elevated blood TMAO levels are associated with heart attack, stroke and …

Vascular endothelial dysfunction, a characteristic of the aging process, is an important risk
factor for cardiovascular disease in aging. Although, vascular inflammation and oxidative …

Background Trimethylamine‐N‐oxide (TMAO), a metabolite derived from gut microbes and
dietary phosphatidylcholine, is linked to both coronary artery disease pathogenesis and …

Since elevated serum levels of trimethylamine N-oxide (TMAO) were first associated with
increased risk of cardiovascular disease (CVD), TMAO research among chronic diseases …

Background Production of the proatherogenic metabolite, trimethylamine N‐oxide (TMAO),
from dietary nutrients by intestinal microbiota enhances atherosclerosis development in …

ABSTRACT Background Trimethylamine-N-oxide (TMAO), a diet-derived and gut microbiota–
related metabolite, is associated with cardiovascular disease (CVD). However, major dietary …