Longitudinal plasma measures of trimethylamine N‐oxide and risk of atherosclerotic cardiovascular disease events in community‐based older adults

Y Lee, I Nemet, Z Wang, HTM Lai… - Journal of the …, 2021 - Am Heart Assoc
Background Trimethylamine N‐oxide (TMAO) is a gut microbiota‐dependent metabolite of
dietary choline, L‐carnitine, and phosphatidylcholine‐rich foods. On the basis of …

Long-term changes in gut microbial metabolite trimethylamine N-oxide and coronary heart disease risk

Y Heianza, W Ma, JA DiDonato, Q Sun… - Journal of the American …, 2020 - jacc.org
Background A gut-microbial metabolite, trimethylamine N-oxide (TMAO), has been
associated with coronary atherosclerotic burden. No previous prospective study has …

[HTML][HTML] Associations of plasma trimethylamine N-oxide, choline, carnitine, and betaine with inflammatory and cardiometabolic risk biomarkers and the fecal …

BC Fu, MAJ Hullar, TW Randolph, AA Franke… - The American journal of …, 2020 - Elsevier
ABSTRACT Background Trimethylamine N-oxide (TMAO), a compound derived from diet
and metabolism by the gut microbiome, has been associated with several chronic diseases …

Microbiota-derived metabolite trimethylamine N-oxide protects mitochondrial energy metabolism and cardiac functionality in a rat model of right ventricle heart failure

M Videja, R Vilskersts, S Korzh, H Cirule… - Frontiers in cell and …, 2021 - frontiersin.org
Aim: Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite synthesized in
host organisms from specific food constituents, such as choline, carnitine and betaine …

Trimethylamine/trimethylamine-N-oxide as a key between diet and cardiovascular diseases

S He, H Jiang, C Zhuo, W Jiang - Cardiovascular Toxicology, 2021 - Springer
Trimethylamine (TMA) is a gut microbiota-derived metabolite which comes from diets rich of
choline, betaine or l-carnitine and could be further converted to Trimethylamine-N-oxide …

Microbiota‐dependent metabolite trimethylamine‐N‐oxide is associated with disease severity and survival of patients with chronic heart failure

M Trøseid, T Ueland, JR Hov, A Svardal… - Journal of internal …, 2015 - Wiley Online Library
Objectives Recent metabolomic, experimental and clinical studies have demonstrated that
trimethylamine‐N‐oxide (TMAO), a microbiota‐dependent metabolite from dietary …

Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney …

WHW Tang, Z Wang, DJ Kennedy, Y Wu… - Circulation …, 2015 - Am Heart Assoc
Rationale: Trimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary
choline, phosphatidylcholine (lecithin), and l-carnitine, is elevated in chronic kidney …

[HTML][HTML] Gut microbiota–derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis

D Li, Y Lu, S Yuan, X Cai, Y He, J Chen, Q Wu… - The American journal of …, 2022 - Elsevier
ABSTRACT Background Trimethylamine-N-oxide (TMAO) is a gut microbiota–derived
metabolite produced from dietary nutrients. Many studies have discovered that circulating …

Impaired renal function and dysbiosis of gut microbiota contribute to increased trimethylamine-N-oxide in chronic kidney disease patients

KY Xu, GH Xia, JQ Lu, MX Chen, X Zhen, S Wang… - Scientific Reports, 2017 - nature.com
Chronic kidney disease (CKD) patients have an increased risk of cardiovascular diseases
(CVDs). The present study aimed to investigate the gut microbiota and blood trimethylamine …

Trimethylamine N‐oxide and cardiovascular outcomes in patients with chronic heart failure after myocardial infarction

X Zhou, M Jin, L Liu, Z Yu, X Lu, H Zhang - ESC heart failure, 2020 - Wiley Online Library
Aim Accumulating evidence has demonstrated that intestinal microbiota‐dependent
trimethylamine N‐oxide (TMAO) is involved in the pathogenesis of various cardiovascular …