Gut microbiota-dependent trimethylamine-N-oxide (TMAO) shows a U-shaped association with mortality but not with recurrent venous thromboembolism

MF Reiner, D Müller, S Gobbato, O Stalder… - Thrombosis research, 2019 - Elsevier
Introduction Gut microbiota-dependent trimethylamine-N-oxide (TMAO) correlates with
arterial thrombotic events including myocardial infarction and stroke, and mortality. However …

Major increase in microbiota-dependent proatherogenic metabolite TMAO one year after bariatric surgery

M Trøseid, JR Hov, TK Nestvold… - … syndrome and related …, 2016 - liebertpub.com
Abstract Background: Trimethylamine-N-oxide (TMAO) is formed in the liver from
trimethylamine (TMA), a product exclusively generated by the gut microbiota from dietary …

TMAO is associated with mortality: impact of modestly impaired renal function

EG Gruppen, E Garcia, MA Connelly, EJ Jeyarajah… - Scientific reports, 2017 - nature.com
Abstract Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared
by the kidney and linked to renal function. We explored the relationship between TMAO and …

Gut Microbial Metabolite Trimethylamine N-Oxide Aggravates Pulmonary Hypertension

Y Huang, F Lin, R Tang, C Bao, Q Zhou… - American Journal of …, 2022 - atsjournals.org
Trimethylamine N-oxide (TMAO), a metabolite derived from intestine microbial flora,
enhances vascular inflammation in a variety of cardiovascular diseases, and the bacterial …

Associations among serum trimethylamine-N-oxide (TMAO) levels, kidney function and infarcted coronary artery number in patients undergoing cardiovascular …

A Mafune, T Iwamoto, Y Tsutsumi, A Nakashima… - Clinical and …, 2016 - Springer
Abstract Background Trimethylamine-N-oxide (TMAO) is a metabolite of phosphatidylcholine
generated by gut microbiota and liver enzymes, and has recently been recognized as …

Microbiology meets big data: the case of gut microbiota–derived trimethylamine

G Falony, S Vieira-Silva, J Raes - Annual review of microbiology, 2015 - annualreviews.org
During the past decade, meta-omics approaches have revolutionized microbiology, allowing
for a cultivation-free assessment of the composition and functional properties of entire …

Relation of circulating trimethylamine N-oxide with coronary atherosclerotic burden in patients with ST-segment elevation myocardial infarction

Z Sheng, Y Tan, C Liu, P Zhou, J Li, J Zhou… - The American journal of …, 2019 - Elsevier
The gut microbial metabolite trimethylamine N-oxide (TMAO) promotes atherosclerosis and
cardiovascular diseases. TMAO levels are associated with the coronary atherosclerotic …

TMAO as a potential biomarker and therapeutic target for chronic kidney disease: A review

Y Zixin, C Lulu, Z Xiangchang, F Qing… - Frontiers in …, 2022 - frontiersin.org
The gut microbiota and its metabolites have become a hotspot of recent research.
Trimethylamine N-oxide (TMAO) metabolized by the gut microbiota is closely related to …

Dysbiosis of gut microbiota with reduced trimethylamine‐N‐oxide level in patients with large‐artery atherosclerotic stroke or transient ischemic attack

J Yin, SX Liao, Y He, S Wang, GH Xia… - Journal of the …, 2015 - Am Heart Assoc
Background Gut microbiota has been suggested to play a role in almost all major diseases
including cardio‐and cerebrovascular diseases. A possible mechanism is the transformation …

Gut microbial taxa as potential predictive biomarkers for acute coronary syndrome and post-STEMI cardiovascular events

J Gao, KT Yan, JX Wang, J Dou, J Wang, M Ren… - Scientific reports, 2020 - nature.com
Plasma trimethylamine N-oxide (TMAO) is associated with coronary atherosclerotic plaque
and cardiovascular disease risk, but associations between gut microbes in acute coronary …