The von Hippel–Lindau tumor suppressor gene
K Kondo, WG Kaelin Jr - Experimental cell research, 2001 - Elsevier
Germline mutations of the von Hippel–Lindau tumor suppressor gene (VHL) in humans
causes a hereditary cancer syndrome characterized by the development of retinal and …
causes a hereditary cancer syndrome characterized by the development of retinal and …
Role of VHL Gene Mutation in Human Cancer
WY Kim, WG Kaelin - Journal of clinical oncology, 2004 - ascopubs.org
Germline inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene causes the
von Hippel-Lindau hereditary cancer syndrome, and somatic mutations of this gene have …
von Hippel-Lindau hereditary cancer syndrome, and somatic mutations of this gene have …
von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF
MA Hoffman, M Ohh, H Yang, JM Klco… - Human molecular …, 2001 - academic.oup.com
Abstract von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome caused by germ
line mutation of the von Hippel-Lindau tumor suppressor gene (VHL). Tumors observed in …
line mutation of the von Hippel-Lindau tumor suppressor gene (VHL). Tumors observed in …
The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma
WG Kaelin Jr - Clinical Cancer Research, 2007 - AACR
Germ line VHL tumor suppressor gene loss-of-function mutations cause von Hippel-Lindau
disease, which is associated with an increased risk of central nervous system …
disease, which is associated with an increased risk of central nervous system …
von Hippel–Lindau tumor suppressor: not only HIF's executioner
MF Czyzyk-Krzeska, J Meller - Trends in molecular medicine, 2004 - cell.com
Abstract Loss of von Hippel–Lindau (VHL) protein function results in an autosomal-dominant
cancer syndrome known as VHL disease, which manifests as angiomas of the retina …
cancer syndrome known as VHL disease, which manifests as angiomas of the retina …
In vitro and In vivo Models Analyzing von Hippel-Lindau Disease-Specific Mutations
WK Rathmell, MM Hickey, NA Bezman, CA Chmielecki… - Cancer research, 2004 - AACR
Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene cause tissue-specific
tumors, with a striking genotype-phenotype correlation. Loss of VHL expression predisposes …
tumors, with a striking genotype-phenotype correlation. Loss of VHL expression predisposes …
The von Hippel-Lindau tumor suppressor protein: roles in cancer and oxygen sensing
WG Kaelin - Cold Spring Harbor symposia on quantitative …, 2005 - symposium.cshlp.org
Biallelic inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene is a common
event in hereditary (von Hippel-Lindau disease) and sporadic hemangioblastomas and …
event in hereditary (von Hippel-Lindau disease) and sporadic hemangioblastomas and …
Role of VHL gene mutation in human renal cell carcinoma
W Arjumand, S Sultana - Tumor Biology, 2012 - Springer
Abstract The Von Hippel–Lindau (VHL) is an inherited neoplasia syndrome caused by the
inactivation of VHL tumor suppressor gene, and somatic mutation of this gene has been …
inactivation of VHL tumor suppressor gene, and somatic mutation of this gene has been …
Cloning and characterization of a mouse gene with homology to the human von Hippel-Lindau disease tumor suppressor gene: implications for the potential …
J Gao, JG Naglich, J Laidlaw, JM Whaley, BR Seizinger… - Cancer research, 1995 - AACR
Abstract The human von Hippel-Lindau disease (VHL) gene has recently been identified
and, based on the nucleotide sequence of a partial cDNA clone, has been predicted to …
and, based on the nucleotide sequence of a partial cDNA clone, has been predicted to …
The von Hippel-Lindau tumor suppressor gene and kidney cancer
WG Kaelin Jr - Clinical cancer research, 2004 - AACR
Abstract The von Hippel-Lindau tumor suppressor gene (VHL), which resides on
chromosome 3p25, is mutated or silenced in> 50% of sporadic clear cell renal cell …
chromosome 3p25, is mutated or silenced in> 50% of sporadic clear cell renal cell …