Different dose regimes and administration methods of tranexamic acid in cardiac surgery: a meta-analysis of randomized trials
J Guo, X Gao, Y Ma, H Lv, W Hu, S Zhang, H Ji… - BMC …, 2019 - Springer
Background The efficacy of tranexamic acid (TXA) to reduce perioperative blood loss and
allogeneic blood transfusion in cardiac surgeries has been proved in previous studies, but …
allogeneic blood transfusion in cardiac surgeries has been proved in previous studies, but …
Comparison of two doses of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass
S Sigaut, B Tremey, A Ouattara, R Couturier… - …, 2014 - pubs.asahq.org
Background: The optimal dose of tranexamic acid (TA) is still an issue. The authors
compared two doses of TA during cardiac surgery in a multicenter, double-blinded …
compared two doses of TA during cardiac surgery in a multicenter, double-blinded …
Exclusion criteria and adverse events in perioperative trials of tranexamic acid: a systematic review and meta‐analysis
J Yates, I Perelman, S Khair, J Taylor, J Lampron… - …, 2019 - Wiley Online Library
BACKGROUND Tranexamic acid (TXA) is an inexpensive therapy effective at minimizing
perioperative blood loss and transfusion. However, it remains underutilized due to safety …
perioperative blood loss and transfusion. However, it remains underutilized due to safety …
Exposure–response relationship of tranexamic acid in cardiac surgery: a model-based meta-analysis
PJ Zufferey, J Lanoiselee, B Graouch, B Vieille… - …, 2021 - pubs.asahq.org
Background It is unclear whether high-dose regimens of tranexamic acid in cardiac surgery
(total dose, 80 to 100 mg/kg) confer a clinical advantage over low-dose regimens (total dose …
(total dose, 80 to 100 mg/kg) confer a clinical advantage over low-dose regimens (total dose …
Effect of high-vs low-dose tranexamic acid infusion on need for red blood cell transfusion and adverse events in patients undergoing cardiac surgery: the OPTIMAL …
J Shi, C Zhou, W Pan, H Sun, S Liu, W Feng, W Wang… - Jama, 2022 - jamanetwork.com
Importance Tranexamic acid is recommended for reducing blood loss and transfusion in
cardiac surgery. However, it remains unknown whether a high dose of tranexamic acid …
cardiac surgery. However, it remains unknown whether a high dose of tranexamic acid …
Moderate dosage of tranexamic acid during cardiac surgery with cardiopulmonary bypass and convulsive seizures: incidence and clinical outcome
A Koster, J Börgermann, A Zittermann… - British journal of …, 2013 - academic.oup.com
Background Convulsive seizures (CS) occur in∼ 1% of the patients after cardiac surgery
with cardiopulmonary bypass. Recent investigations indicate an up to seven-fold increase in …
with cardiopulmonary bypass. Recent investigations indicate an up to seven-fold increase in …
Update on applications and limitations of perioperative tranexamic acid
PA Patel, JA Wyrobek, AJ Butwick… - Anesthesia & …, 2022 - journals.lww.com
Tranexamic acid (TXA) is a potent antifibrinolytic with documented efficacy in reducing blood
loss and allogeneic red blood cell transfusion in several clinical settings. With a growing …
loss and allogeneic red blood cell transfusion in several clinical settings. With a growing …
Tranexamic acid administration after cardiac surgery: a prospective, randomized, double-blind, placebo-controlled study
V Casati, F Bellotti, C Gerli, A Franco… - The Journal of the …, 2001 - pubs.asahq.org
Background Many different doses and administration schemes have been proposed for the
use of the antifibrinolytic drug tranexamic acid during cardiac surgery. This study evaluated …
use of the antifibrinolytic drug tranexamic acid during cardiac surgery. This study evaluated …
Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss
K Ker, D Prieto-Merino, I Roberts - Journal of British Surgery, 2013 - academic.oup.com
Background Tranexamic acid (TXA) reduces blood transfusion in surgery but the extent of
the reduction in blood loss and how it relates to the dose of TXA is unclear. Methods A …
the reduction in blood loss and how it relates to the dose of TXA is unclear. Methods A …
A single preoperative dose of tranexamic acid reduces perioperative blood loss: a meta-analysis
M Heyns, P Knight, AK Steve, JK Yeung - Annals of surgery, 2021 - journals.lww.com
Objective: To review the efficacy and safety of a single dose of intravenous tranexamic acid
(TXA) given preoperatively. Summary Background Data: TXA is a synthetic antifibrinolytic …
(TXA) given preoperatively. Summary Background Data: TXA is a synthetic antifibrinolytic …
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